Methodologies for the diagnosis and treatment of gastroesophageal reflux disease
OwnerParakrama Chandrasomainventor
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Abstract
A novel methodology for diagnosing and treating gastroesophageal reflux disease is provided. These methodologies are based on the discovery of a new disease mechanism called hereinafter “reflux carditis”, which is a novel mechanistic view of reflux disease that recognizes cardiac mucosa, which has heretofore been regarded as a normal epithelium in the stomach and an abnormal epithelium in the esophagus, as an abnormal mucosa in both the esophagus and stomach.
Claims63
A method of diagnosing a gastroesophageal disorder comprising:
- examining at least one of either the esophageal epithelial or the gastric mucosa of a patient;
- determining the presence or absence of the gastroesophageal disorder based on a histological observation of the condition of the at least one of either the esophageal epithelial or the gastric mucosa of the patient.
A method of diagnosing a patient's risk of developing reflux-induced adenocarcinoma of the esophagus comprising:
- determining the presence or absence of a columnar lined esophagus and the length thereof;
- identifying the nature of the abnormal epithelia in the columnar lined esophagus;
- measuring the pH gradient from the gastroesophageal junction to the proximal esophagus;
- determining the presence or absence of intestinal metaplasia and the location thereof along the esophagus;
- and
- determining whether the patient has gastroesophageal reflux disease.
A method of treating a gastroesophageal disorder in a patient comprising:
- providing a therapeutic course of treatment to prevent or reverse a disorder triggered transformation of a healthy esophageal epithelium to an unhealthy esophageal epithelium.
A method of screening therapeutic compounds effective for treating a gastroesophageal disorder, comprising:
- exposing at least one sample of epithelial to a plurality of molecular components in gastric juice;
- monitoring said at least one sample for columnar cellular transformation.
Dependencies are inferred from the claim text.