US 2007/0178507 A1 · Method and apparatus for detection of molecules using nanopores

Abstract

A molecular analysis device comprises a molecule sensor and a nanopore that passes through, partially through, or substantially near the molecule sensor. The molecule sensor may comprise a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. The molecular sensor may also comprise a nanowire that operably couples a first and a second terminal. A nitrogenous material that may be disposed on at least part of the molecule sensor is configured for a chemical interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to a molecule or responsive to a chemical interaction.

Claims20

Dependent claims

A molecular analysis device, comprising:

at least one molecule sensor, wherein the at least one sensor is selected from the group consisting of a single electron transistor and a nanowire;
at least one nanopore passing at least partially through or substantially near the at least one molecule sensor;
and
wherein the at least one molecule sensor develops an electronic effect responsive to a molecule passing through the at least one nanopore.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

11/655,388Filed 19 Jan 2007

Priority

31 Jan 2006

Published

2 Aug 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

G01N 33/48721
By electrical means: investigating individual macromolecules, e.g. by translocation through nanopores
C12Q 1/6825
Characterised by the detection means: nucleic acid detection involving sensors
G01N 33/54373
Apparatus specially adapted for solid-phase testing: involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
C12Q 1/6869
Involving nucleic acids: methods for sequencing

Method and apparatus for detection of molecules using nanopores

Life of this patent

Method and apparatus for detection of molecules using nanopores

Life of this patent

Abstract

Claims20