Extended dynamic range reading of chemical arrays
OwnerJohn F. Corson, Bo Curry +2inventors
InventorsJohn F. Corson, Bo Curry, Charles Troup, Xiangyang Zhou
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Abstract
Methods of reading chemical arrays are provided. Aspects of the methods include reading an array at a first and second detector gain setting to produce linked data sets of an array, where each reading may be made using a different detector gain setting. Aspects of the methods further include extracting features from the linked data sets, where in certain embodiments a merged data set feature extraction protocol is employed. Aspects of the invention further include programming for operating devices, e.g., chemical array readers, as well as readers comprising such programming.
Claims25
A method of reading a chemical array, said method comprising:
- (a) positioning said array in a reading position of a chemical array reader;
- (b) reading said array a first time in said scan position at a first detector gain setting to produce a first data set;
- and
- (c) before moving said array out of said reading position re-reading said array at a second detector gain setting to produce a second data set.
A method of extracting features from two or more linked data sets of a chemical array, said method comprising:
- (a) determining whether said linked data sets should be merged or used separately;
- and
- (b) if a decision is made to merge said linked data sets;
- (i) converting signals in said linked data sets to background subtracted signals;
- (ii) combining said background-subtracted signals into a merged set.
Dependencies are inferred from the claim text.