Nanotube sensor devices for DNA detection

A method for making a nanoelectronic sensor, comprising:

• disposing a film of nanotubes over electrodes on a substrate;
• depositing a solution of single-stranded DNA over the substrate, wherein the single-stranded DNA is configured as a complement to a target DNA sequence;
• and
• drying the solution to leave a deposit of the single-stranded DNA over the substrate.

An electronic sensor system for target polynucleotides, comprising:

• (a) at least one sensor platform having at least one electrical property, the platform including:
• a substrate,
• at least one electrode disposed adjacent the substrate, and
• at least one nanostructured element disposed adjacent the substrate, the nanostructured element in electrical communication with the electrode;
• (b) at least one detector probe operatively associated with the sensor platform, the probe including:
• a linker group disposed in association with the sensor platform, the linker being connected to one or more of the following:
• the nanostructured element, the substrate, and the electrode;
• a detector biomolecule having a binding affinity to an analyte polynucleotide.
• a bonding connection between the linker group and the detector biomolecule;
• and
• (c) electronic measurement circuitry connected to the electrode, and configured to measure the at least one electrical property of the sensor platform.