N,n-dimethylacrylamide-based high molecular weight polymer
AssigneeCommissariat a l'Energie Atomique
InventorsJan Sudor, Valessa Barbier
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Abstract
The invention relates to water-soluble N,N-dialkylacrylamide-based high molecular weight random polymers and monomers laterally functionalised by molecules of interest and to the use thereof for preparing solid supports provided with at least one surface on which said polymers are adsorbed. Said invention also relates to the thus modified solid supports, to a method for the production thereof and to different uses thereof, in particular for immobilising molecules of interest or for carrying out chemical, biochemical or biological reactions.
Claims23
A water-soluble random polymer containing probe molecules as lateral substituents, characterized in that:
- it results from the copolymerization of an N,N-[dialkyl(C1-C4)acrylamide] monomer A and a monomer B selected from probe molecules functionalized with a copolymerizable monomer,
- said probe molecules aforesaid in a) and b) being selected from proteins;
- polysaccharides, oligo-saccharides, nucleic acids and small organic molecules, said lateral substituents being at least two in number per molecule of copolymer,
- it displays a molecular weight which must be greater than 500 000 g/mole, and
- the incorporation ratio of said probe molecules must be lower than 30% in number relative to the total number of N,N-[dialkyl(C1-C4)acrylamide] monomeric units.
Dependencies are inferred from the claim text.