US 2007/0178443 A1Published application

Method for diagnosing liver fibrosis

OwnerUrsula-Henrike Wienhues-Thelen, Paul Cales +1inventors

InventorsUrsula-Henrike Wienhues-Thelen, Paul Cales, Hendrik Huedig

Life of this patent

Estimating the term…

Loading patent…

Abstract

The invention concerns a method for the detection of the presence and/or the severity of a liver disease in a patient comprising measuring in an isolated sample TIMP-1 (Tissue Inhibitor of Metalloproteinase I), A2M (a-2-macroglobulin), PLT (number of blood plateletes, PI (prothrombin index), optionally at least one additional parameter selected from the group consisting of urea and GGT (γ-glutamyltranspeptidase) and optionally measuring at least one additional biochemical or clinical parameter and diagnosing the presence and/or severity of a liver disease based on the presence or measured levels of these parameters. The method can be used for monitoring therapeutic treatment of liver fibrosis and staging of liver fibrosis.

Claims3

Dependent claims

A method for the detection of the presence and/or the severity of a liver disease in a patient comprising

a) obtaining a sample from said patient
b) measuring TIMP-1 (tissue inhibitor of metalloproteinase I) in said sample
b) measuring A2M (a-2-macroglobulin) in said sample
c) measuring PLT (number of blood platelets) in said sample
d) PI (prothrombin index) in said sample
e) optionally measuring or determining at least one additional biochemical or clinical parameter selected from the group consisting of urea and GGT (γ-glutamyltranspeptidase) in said sample
f) optionally measuring at least one additional biochemical or clinical parameter in said sample
g) diagnosing the presence and/or severity of a liver disease based on the presence or measured levels of TIMP-1, A2M, PLT, PI and the parameter measured according to steps e) and f)

5 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/673,072Filed 9 Feb 2007
Priority: EP EP 04019134.812 Aug 2004
Published: 2 Aug 2007
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

G01N 33/6893
Involving proteins, peptides or amino acids: related to diseases not provided for elsewhere
G01N 2333/745
From animals; from humans: assays involving non-enzymic blood coagulation factors
G01N 2333/81
Assays involving biological materials from specific organisms or of a specific nature: protease inhibitors
G01N 2333/8146
Endopeptidase inhibitors: metalloprotease inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP