Method for diagnosing liver fibrosis
OwnerUrsula-Henrike Wienhues-Thelen, Paul Cales +1inventors
InventorsUrsula-Henrike Wienhues-Thelen, Paul Cales, Hendrik Huedig
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Abstract
A method for the detection of the presence and/or the severity of a liver disease in a patient comprising measuring in an isolated sample TIMP-1 (tissue inhibitor of metalloproteinase I), ferritin, at least one additional parameter selected from the group consisting of A2M (alpha-2-macroglobulin) and PI (prothrombin index) and optionally measuring at least one additional biochemical or clinical parameter and diagnosing the presence and/or severity of a liver disease based on the presence or measured levels of these parameters. The method can be used for monitoring therapeutic treatment of liver fibrosis and staging of liver fibrosis.
Claims4
A method for the detection of the presence or severity of a liver disease in a patient comprising the steps of:
- providing a sample from said patient,
- measuring TIMP-1 (tissue inhibitor of metalloproteinase I) in said sample,
- measuring ferritin in said sample,
- measuring at least one additional parameter selected from the group consisting of A2M (α-2-macroglobulin) and PI (prothrombin index) in said sample, and
- diagnosing the presence or severity of a liver disease based on the presence or measured levels of TIMP-1, ferritin, and the additional parameter measured.
Dependencies are inferred from the claim text.