Method of Drug Interaction

A method of metabolizing a drug in a cell culture tray having six wells surrounded by a containing wall, the method comprising:

• depositing a first cell type in a first well, a second cell type in a second well, a third cell type in a third well, a fourth cell type in a fourth well, a fifth cell type in a fifth well, and a sixth cell type in a sixth well;
• overfilling the first, second, third, fourth, fifth, and sixth well to cause the first, second, third, fourth, fifth, and sixth cell type to interact via a common fluid medium;
• and
• introducing the drug into the common fluid medium.

A method of interacting a drug with an in vivo system having multiple cell types to model a drug interaction with a living organism in a cell culture tool having a flat plate segregated into multiple chamber units, each of the chamber units having a chamber wall surrounding multiple wells with the height of the chamber wall being taller than that of the height of the surrounded multiple wells, the method comprising:

• depositing a different cell type in the set of wells in each chamber;
• adding a fluid medium to a height above the flat surface to fluidly interconnect the set of wells in each chamber;
• and
• adding the drug to the fluid medium in each chamber, the dose and type of the drug being varied in each chamber.