Inhibitors of gob-4 protein as asthma therapeutics
AssigneeWyeth
InventorMaximillian Follettie
Life of this patent
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Abstract
Methods of screening for agents for treating asthma are provided. The methods involve screening for agents that decrease the production or activity of a Gob-4 protein that has been discovered herein to play a role in producing the symptoms and pathological complications involved in asthma. Methods of treating asthma, as well as screening for and treating with inhibitors of a Gob-4 protein are also provided.
Claims20
A method of screening for agents for treating asthma in a human, comprising:
- (a) contacting a mammalian Gob-4 protein with a test agent thought to be effective in inhibiting the activity of said mammalian Gob-4 protein;
- (b) determining if said test agent inhibits the activity of said mammalian Gob4 protein, wherein determining if said test agent inhibits the activity of said mammalian Gob-4 protein comprises quantitating the amount of mucus produced by staining said mucus with a periodic-acid Schiff stain;
- and
- (c) classifying said test agent as an agent for treating asthma if said test agent inhibits the activity of said mammalian Gob4 protein.
A method of screening for agents for treating asthma in a mammal, comprising:
- (a) contacting a Gob-4 protein with a test agent thought to be effective in inhibiting the activity of said Gob-4 protein;
- (b) determine if said test agent inhibits the activity of said Gob-4 protein;
- and
- (c) classifying said test agent as an agent for treating asthma if said test agent inhibits the activity of said Gob-4 protein.
A method of screening for agents for treating asthma in a mammal, comprising:
- (a) contacting a nucleotide sequence encoding a reporter gene product operably linked to a Gob-4 protein promoter with a test agent thought to be effective in inhibiting production of a Gob-4 protein;
- (b) determining if said test agent inhibits production of said reporter gene product;
- and
- (c) classifying said test agent as an agent for treating asthma if said test agent inhibits production of said reporter gene product.
A method for treating asthma, comprising administering to a mammal in need thereof a therapeutic amount of an agent that decreases the activity of a Gob-4 protein.
A method for treating asthma, comprising administering to a mammal in need thereof a therapeutic amount of an agent that decreases the production of a Gob-4 protein.
Dependencies are inferred from the claim text.