Methods and compositions for the production of high concentration alloxazine solutions
AssigneeCaridianBCT Biotechnologies, LLC
InventorsEric T. Hansen, Raymond P. Goodrich
Life of this patent
Estimating the term…
Abstract
Methods are provided for preparation of compositions having an enhanced level of soluble alloxazine, as compared to compositions prepared using conventional techniques. Compositions and a riboflavin form having higher solubility in solution is also provided.
Claims22
A method of increasing the concentration of an alloxazine in an aqueous medium to above the alloxazine's saturation point, the method comprising:
- adding an amount of said alloxazine to said aqueous medium, wherein the amount of alloxazine exceeds the saturation point of said alloxazine at 1 atmosphere and 22° C.;
- heating said aqueous medium to a temperature equal to or greater than 80° C.;
- and
- cooling said aqueous medium to produce an aqueous medium having a concentration of alloxazine above the alloxazine saturation point.
A method for inactivating pathogens in a biological fluid comprising:
- adding a composition comprising at least 120 μM soluble alloxazine to the biological fluid to inactivate the biological pathogens in the biological fluid.
A riboflavin derivative form having a correlation coefficient equal to or less than 0.95 at a wavelength of 525 nm and an absorbance profile as a function of concentration that differs from soluble riboflavin at wavelengths above 500 nm.
A composition for treating a blood product comprising:
- between about 150 μM and about 580 μM soluble alloxazine;
- and
- a monovalent salt.
Dependencies are inferred from the claim text.