Process for production of ionically crosslinked polysaccharide microspheres
AssigneeEyeSense AG
InventorsStefan Kammermeier, Till Merkel, Katharina Schmid, Achim Muller
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Abstract
The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the micro-spheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
Claims22
1-17. (canceled)
A process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising:
- (a) producing liquid aerosol droplets from a solution comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer;
- (b) transferring the gas stream into a gelling solution comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres are formed, and
- (c) separating the microspheres from the gelling solution.
A system for preparing microspheres comprising an ionically crosslinked polymer, the system comprising:
- (a) an ultra sound generator situated in a nebulizing chamber which is filled with a solution comprising an ionically crosslinkable polymer;
- (b) a radiator coil attached to the nebulizing chamber;
- (d) a gas inlet attached to the nebulizing chamber
- (e) a vessel for the gelling solution, equipped with agitation means;
- and
- (f) a transfer tubing attached to the nebulizing chamber, connecting nebulizing chamber and vessel, wherein the tubing is adapted to submerge into the gelling solution.
Dependencies are inferred from the claim text.