US 2007/0178158 A1 · Stabilized bone graft

Abstract

A demineralized bone matrix (DBM) or other matrix composition is provided that has been stabilized by lowering the pH of the composition, reducing the water content, adding water substitutes, and/or increasing the amount of deuterated water present in the composition in order to reduce the activity of endogenous degrading enzymes such as proteases. A hydrated form of a stabilized DBM composition may be stable up to a year at room temperature at acidic pH. The acidified DBM compositions may be further stabilized by the addition of a stabilizing agent such as deuterated water, water substitutes, polymers, protease inhibitors, glycerol, hydrogels, etc. The invention also provides methods of preparing, testing, and using the inventive stabilized osteodinductive matrix compositions.

Claims34

Dependent claims

A demineralized bone matrix composition comprising:

demineralized bone matrix;
at least one non-glycercol stabilizing means;
wherein the composition retains at least 50% of its original osteoinductivity after one year at room temperature.

Dependencies are inferred from the claim text.

Facts

Application

10/589,226Filed 27 Jan 2005

Priority

27 Jan 2004

Published

2 Aug 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61L 27/3608
Characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura,…
A61K 31/728
Glycosaminoglycans, i.e. mucopolysaccharides: hyaluronic acid
A61K 35/32
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61K 38/55
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: protease inhibitors

Stabilized bone graft

Life of this patent

Stabilized bone graft

Life of this patent

Abstract

Claims34