Preparation for gastric buoyant sustained drug release dosage form
OwnerDavid YiHai Jianginventor
Life of this patent
Estimating the term…
Abstract
Disclosed is a floating sustained release pharmaceutical dosage form including a drug that is adapted to release the drug over an extended period of time. The buoyant pharmaceutical dosage form provides extended gastric residence time of the formulation so that substantially all of the drug is released in the stomach over an extended period. The pharmaceutical dosage form is formulated with low molecular weight concentrated milk proteins to provide buoyancy to the dosage form which can float in gastric fluid for an extended period, including up to about 48 hours.
Claims37
A pharmacologically active gastric buoyant composition having extended gastric residence time with sustained drug release, said composition comprising:
- at least one pharmacologically active compound,
- at least one pharmacologically acceptable additive, and
- low molecular weight concentrated milk proteins;
- wherein the composition is compressed to a hardness of less than about 25 kp.
A pharmacologically active gastric buoyant composition having extended gastric residence time with sustained drug release, said composition comprising:
- at least one pharmacologically active compound,
- at least one pharmacologically acceptable additive,
- low molecular weight concentrated milk proteins, and
- one or more polymers.
A pharmacologically active gastric buoyant composition having extended gastric residence time with sustained drug release, said composition comprising:
- at least one pharmacologically active compound,
- one or more fatty materials,
- low molecular weight concentrated milk proteins, and
- one or more polymers.
Dependencies are inferred from the claim text.