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US 2007/0178154 A1Published application
Calcium Carbonate Granulation
AssigneeDelavau LLC
InventorsRaya Levin, Kevin Lang, Gregory Murphy, James Dibble
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Abstract
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
Claims25
A process for preparing a calcium carbonate granulation comprising the steps of:
- (a) mixing, in a mixer capable of creating high shear, a composition comprising:
- (i) calcium carbonate powder having a median particle diameter between about 0.1 to about 20 μm;
- (ii) water;
- and
- (iii) one or more excipients selected from the group consisting of diluents, binders, glidants, lubricants, disintegrants, colors, flavors, sweeteners, solubility retarding agents, and combinations thereof;
- and
- (b) drying the composition to a water content of less than about 1% by weight in a drier selected from the group consisting of a tray dryer, a vertical fluidized bed oven, a horizontal fluidized bed oven, a spray dryer, and an impingement oven;
- to provide a calcium carbonate granulation.
5 more elements
Dependencies are inferred from the claim text.