Pharmaceutical compositions
OwnerPrasad Adusumilli, Chungbin Kim +3inventors
InventorsPrasad Adusumilli, Chungbin Kim, Stanley Itech, Naresh Mehta, Dara Dinner
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Abstract
A pharmaceutical composition in the form of a chewable tablet for the suppression of gastric reflux comprising an alginic acid or salt thereof, a water-soluble carbonate radical precursor, a calcium salt, a first bulk sweetener, and a binding agent. The calcium salt and either or both of the bulk sweetener and the binding agent may be blended via any of wet granulation, spray drying, or compression processes prior to admixture with the alginic acid and the carbonate radical precursor.
Claims79
A pharmaceutical composition for a chewable tablet, comprising in admixture:
- an alginic acid or a salt thereof;
- a water-soluble carbonate radical precursor;
- a calcium salt;
- a first bulk sweetener;
- a binding agent;
- and
- wherein said calcium salt and either or both of said first bulk sweetener and said binding agent are blended via wet granulation prior to admixture with said alginic acid or salt thereof and said carbonate radical precursor.
A pharmaceutical composition comprising calcium carbonate, sugar, mannitol, corn starch, alginic acid, and a carbonate radical precursor selected from the group consisting of potassium bicarbonate, sodium bicarbonate and a combination thereof, wherein the composition is in the form of a chewable tablet.
A pharmaceutical composition for a chewable tablet formed by a process comprising the following steps:
- providing an alginic acid or a salt thereof;
- providing a water-soluble carbonate radical precursor;
- providing a calcium salt;
- providing a first bulk sweetener;
- providing a binding agent;
- mixing said calcium salt and either or both of said bulk sweetener and said binding agent via wet granulation to form a mixture;
- and
- blending said mixture with said alginic acid or salt thereof, said carbonate radical precursor, and with either said first bulk sweetener or said binding agent if not previously mixed with the calcium salt.
A pharmaceutical composition for a chewable tablet, comprising in admixture:
- an alginic acid or a salt thereof;
- a water-soluble carbonate radical precursor;
- a calcium salt;
- a first bulk sweetener;
- and
- a binding agent.
79-216. (canceled)
Dependencies are inferred from the claim text.