Preparations of growth hormone
AssigneeFraunhofer USA, Inc.
InventorsVidadi Yusibov, Shailaja Rabindran, Marina Skarjinskaia, Oleg Fedorkin, Burt Ensley
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Abstract
The present invention relates to compositions and systems for expressing pharmaceutically active gene products in plants. In particular, the invention provides compositions, systems and methods for the production of human growth hormone in plants. Provided are nucleic acid and protein sequences, expression and vector constructs, host cells and plants capable of expressing human growth hormone, and compositions and kits comprising produced human growth hormone. Additionally provided are methods for production and use of the compositions of the invention. Therapeutic use of the produced human growth hormone is also provided
Claims21
A method of delivering a physiologically significant amount of growth hormone or a pharmaceutically active portion thereof to a mammalian subject comprising steps of:
- administering a composition comprising growth hormone or a pharmaceutically active portion thereof to the subject;
- wherein the growth hormone of the composition is produced in plants and wherein a physiological effect of the administered growth hormone is elicited.
A composition comprising pharmaceutically active growth hormone or a portion thereof, wherein the growth hormone is produced in a plant or a portion thereof.
-102. (canceled)
A plant or portion thereof comprising a nucleic acid encoding growth hormone or a pharmaceutically active portion thereof, wherein the plant is capable of producing the growth hormone protein or pharmaceutically active portion thereof, and wherein the produced growth hormone has pharmaceutical activity when administered to a subject.
Dependencies are inferred from the claim text.