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US 2007/0178134 A1Published application
Pyridines and uses thereof
AssigneeCell Therapeutics, Inc.
InventorsFeng Hong, J. Klein
Life of this patent
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Abstract
The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
Claims59
A compound or physiologically acceptable salt thereof, wherein the compound has the formula:
- wherein:
- X, Y and Z are N, CH or CR where R is alkyl, alkoxy, Cl, Br, NH2, NHR′ or NR′R″ where R′ and R″ independently are alkyl;
- Q is NR, RN—(CH2)n, (CH2)n—NR, O, O—(CH2)n, (CH2)n—O, S, S—(CH2)n, or (CH2)n—S, where n is 1-10 and R is H or alkyl;
- R1 is H, OH, alkyl, alkoxy, Cl, F, Br, CR3 where R3 is Cl3, F3 or Br3, NH2, NHR or NRR′ where R and R′ independently are alkyl;
- R2 is H, OH, alkyl, alkoxy, Cl, F, Br or CR3 where R3 is Cl3, F3 or Br3;
- R3 is H, alkyl, alkoxy, Cl, CCl3, NH2, NHR or NRR′ where R and R′ independently are alkyl or acyl;
- R4, R5, and R are independently H, OH, alkyl, alkenyl, alkynyl, alkoxy, (CH2)n—OR where R is H or alkyl and n is 1-10, Cl, F, Br, CR3 where R3 is Cl3, F3 or Br3 heterocycle, N+(═O)O−, C≡N, N3, SH, SR or S(═O)2R where R is alkyl, NH2, NHR or NRR′ where R and R′ independently are alkyl, or R4 and R5 or R5 and R6 are taken together with the benzene ring to form a heterocycle;
- and with the proviso that one of X, Y and Z is N.
5 more elements
Dependencies are inferred from the claim text.