Cohesive osteogenic putty and materials therefor
AssigneeWarsaw Orthopedic, Inc.
InventorsWilliam McKay, Steve Peckham, Jeffrey Scifert
Life of this patent
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Abstract
Described is an implantable medical material comprising a malleable, cohesive, shape-retaining putty including mineral particles, insoluble collagen fibers and soluble collagen. The medical material can be used in conjunction with biologically active factors such as osteogenic proteins to treat bone or other tissue defects in patients.
Claims36
An implantable osteogenic medical material, comprising:
- a malleable, cohesive, shape-retaining putty comprising 60% to 75% by weight of an aqueous liquid medium and including a bone morphogenic protein incorporated at a level of about 0.6 mg/cc to about 2 mg/cc of the putty;
- said putty including mineral particles dispersed therein having an average particle diameter in the range of 0.4 (mm) to 5 mm at a level of 0.25 g/cc to 0.35 g/cc in the putty;
- said putty further including insoluble collagen fibers at a level of 0.04 g/cc to 0.1 g/cc of the putty, and soluble collagen at a level of 0.01 g/cc to 0.08 g/cc of the putty;
- and
- with the further proviso that the weight ratio of insoluble collagen fibers to soluble collagen in the putty is in the range of 4:1 to 1:1.
An implantable medical material, comprising a malleable, cohesive, shape-retaining putty comprised 60% to 75% by weight of an aqueous liquid medium, dispersed mineral particles having an average particle diameter in the range of 0.4 mm to 5 mm at a level of 0.25 g/cc to 0.35 g/cc of the putty, insoluble collagen fibers at a level of 0.04 g/cc to 0.1 g/cc of the putty, and soluble collagen at a level of 0.01 g/cc to 0.08 g/cc of the putty, with the proviso that the weight ratio of insoluble collagen fibers to soluble collagen is in the range of 4:1 to 1:1.
A method for preparing an implantable osteogenic medical material, comprising:
- providing a dried, porous material that includes a particulate mineral material having an average particle diameter of about 0.4 mm to about 5 mm embedded within a disruptable collagenous matrix, said dried, porous material comprised 70% to 90% by weight of the particulate mineral material and 10% to 30% by weight of collagen, the collagen matrix including insoluble collagen fibers and soluble collagen present in a weight ratio of 4:1 to 1:1;
- and
- applying an aqueous medium to the dried, porous material and disrupting the collagen matrix so as to prepare a malleable, cohesive, shape-retaining putty that comprises 60% to 75% by weight of the aqueous medium.
A medical implant material, comprising:
- a dried porous body including a particulate mineral material having an average particle diameter of 0.4 mm to 5 mm embedded within a disruptable collagen matrix;
- wherein the body is comprises 70% to 90% by weight of the particulate mineral material and 10% to 30% by weight of the collagen;
- wherein the collagen matrix includes insoluble collagen fibers and soluble collagen, with the insoluble collagen fibers and soluble collagen being present in a weight ratio of 4:1 to 1:1;
- and
- wherein the dried porous body is wettable with a biocompatible aqueous medium to form a malleable, cohesive, shape-retaining putty material that includes an admixture of the collagen fibers, aqueous collagen gel, and the particulate mineral material.
Dependencies are inferred from the claim text.