Fusion proteins comprising modified allergens of the ns-ltps family, use thereof and pharmaceutical compositions comprising the same
OwnerDomenico Geraciinventor
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Abstract
The present invention relates to fusion proteins comprising different allergens of the ns-LTPs family, and their use in the prevention and the treatment of allergic symptoms associated to said allergens. In particular, fusion proteins in the form of heterodimers comprising the major allergens of Parietaria judaica, Parj 1 and Parj 2, are described. Methods of preparation of the fusion proteins by expression in genetically modified host cells and pharmaceutical compositions comprising said fusion proteins are described as well.
Claims23
1-22. (canceled)
A fusion protein characterized in that it comprises the amino acid sequences of different allergens belonging to the non-specific Lipid Transfer Protein (ns-LTPs) family, in that said sequences lack one or more of the four disulphide bridges present in the sequences of the wild type allergens, at least one in the amino terminal region comprised between amino acid residues 1 and 30 and in that said sequences maintain essentially the same length as the sequences of wild type allergens.
Dependencies are inferred from the claim text.