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AssigneesSt. Jude Children's Research Hospital, University of Utah Research Foundation
InventorsElisabeth Adderson, John Bohnsack
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This invention provides isolated nucleic acids encoding polypeptides comprising amino acid sequences of streptococcal matrix adhesion (Ema) polypeptides. The invention provides nucleic acids encoding Group B streptococcal Ema polypeptides EmaA, EmaB, EmaC, EmaD and EmaE. The present invention provides isolated polypeptides comprising amino acid sequences of Group B streptococcal polypeptides EmaA, EmaB, EmaC, EmaD and EmaE, including analogs, variants, mutants, derivatives and fragments thereof. Ema homologous polypeptides from additional bacterial species, including S. pneumoniae, S. pyogenes, E. faecalis and C. diptheriae are also provided. Antibodies to the Ema polypeptides and immunogenic fragments thereof are also provided. The present invention relates to the identification and prevention of infections by virulent forms of streptococci. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptides, antibodies thereto, and nucleic acids. Assays for compounds which modulate the polypeptides of the present invention for use in therapy are also provided.
An isolated streptococcal polypeptide EmaA.
An isolated streptococcal polypeptide EmaB.
An isolated streptococcal polypeptide EmaC.
An isolated streptococcal polypeptide EmaD.
An isolated streptococcal polypeptide EmaE.
A vaccine comprising one or more streptococcal polypeptides selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, and a pharmaceutically acceptable adjuvant.
An immunogenic composition comprising one of more streptococcal polypeptides selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, and a pharmaceutically acceptable adjuvant.
A pharmaceutical composition comprising one or more streptococcal polypeptides selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, and a pharmaceutically acceptable carrier.
A purified antibody to a streptococcal polypeptide selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE.
A monoclonal antibody to a streptococcal polypeptide selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE.
A pharmaceutical composition comprising one or more antibodies to a streptococcal protein selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a combination of at least two antibodies to streptococcal proteins and a pharmaceutically acceptable carrier, wherein at least one antibody to a protein selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, is combined with at least one antibody to a protein selected from the group of Spb1 and Spb2, Rib, Lmb, C5a-ase and C protein alpha antigen.
A method for detecting the presence of a streptococcal polypeptide selected from the group of EmaA, EmaB, EmaC, EmaD and EmaE, wherein the streptococcal polypeptide is measured by:
A method for detecting the presence of a bacterium having a gene encoding a streptococcal polypeptide selected from the group of emaA, emaB, emaC, emaD and emaE, comprising:
An isolated streptococcal Ema polypeptide comprising the amino acid sequence set out in SEQ ID NO:23.
An isolated streptococcal Ema polypeptide comprising the amino acid sequence set out in SEQ ID NO:26.
An isolated streptococcal Ema polypeptide comprising the amino acid sequence set out in SEQ ID NO:37.
An enterococcal Ema polypeptide comprising the amino acid sequence set out in SEQ ID NO:29
An isolated Corynebacterium, Ema polypeptide comprising the amino acid sequence set out in SEQ ID No:
An isolated bacterial polypeptide comprising the amino acid sequence TLLTCTPYMINS/THRLLVR/KG (SEQ ID NO:
An isolated streptococcal polypeptide comprising the amino acid sequence TLLTCTPYMINS/THRLLVR/KG (SEQ ID NO:
An isolated bacterial polypeptide comprising the amino acid sequence TLVTCTPYGINTHRLLVTA (SEQ ID NO:
An isolated bacterial polypeptide comprising the amino acid sequence TLVTCTPYGVNTKRLLVRG (SEQ ID NO:
An isolated streptococcal polypeptide comprising the amino acid sequence TLVTCTPYGVNTKRLLVRG (SEQ ID NO:
An isolated polypeptide having the amino acid sequence selected from the group of TLLTCTPYMINS/THRLLVR/KG (SEQ ID NO:
Dependencies are inferred from the claim text.