Method and means for treating solid tumors

In a mammal, a method for treating a vascularized solid tumor, including the steps of:

• a) parenteral administration of a sub-therapeutic dose of at least one small molecular Vascular Disrupting Agent (VDA), to disrupt the endothelial lining of the tumor vasculature, while maintaining adequate rate of blood flow within the tumor vasculature, and thus directly exposing the underlying tumor cells to the circulating blood;
• b) parenteral administration of a number of at least one type of anti-tumor binding component—first ligand complexes;
• c) parenteral administration of a number of anti-ligands;
• d) parenteral administration of a number of, in vitro prepared, blood platelets, each blood platelet carrying at least one anticellular agent and having at least one anti-platelet binding component—second ligand complex attached to its outer surface;
• e) allowing the blood platelets to link to the tumor vasculature through in vivo formation of anti-tumor binding component—first ligand—anti-ligand—second ligand—anti-platelet binding component complexes;
• f) parenteral administration of a number of anti-ligands;
• g) allowing more anticellular agent-carrying blood platelets to link to the blood platelets already linked to the tumor vasculature through in vivo formation of anti-platelet binding component—second ligand—anti-ligand—second ligand—anti-platelet binding component complexes, thereby allowing for the formation of a blood thrombus within the tumor vasculature, leading to occlusion of the tumor vasculature and destruction of the centrally located tumor cells, followed by rupture of the anticellular agent-carrying blood platelets included within the formed blood thrombus, with release of their anticellular agent content;
• and
• h) encouraging the mammal to exercise few times a day, for several days, thereby evenly dispersing the anticellular agent released from the ruptured blood platelets within the debris of the centrally located tumor cells, which enables delivering the anticellular agent to the peripherally located tumor cells.