FHIT proteins and nucleic acids and methods based thereon
OwnerCarlo Croce, Frances Huebnerinventors
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Abstract
The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
Claims22
1-21. (canceled)
An isolated antibody that binds to at least one member selected from the group consisting of SEQ ID NO:2 and a protein having at least 60% identity to SEQ ID NO:2.
A kit comprising an isolated antibody that binds to at least one member selected from the group consisting of SEQ ID NO:2 and a protein having at least 60% identity to SEQ ID NO:2.
Dependencies are inferred from the claim text.