Methods of identifying combinations of antibodies with an improved anti-tumor activity and compositions and methods using the antibodies
AssigneeYeda Research and Development Co. Ltd.
InventorsYosef Yarden, Michael Sela
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Abstract
A method of identifying a combination of antibodies with a combined improved anti tumor activity is provided. The method comprising identifying at least two anti RTK antibodies capable of inducing synergistic endocytosis of the RTK in a cell expressing the RTK, thereby identifying the combination of antibodies with the combined improved anti-tumor activity.
Claims65
A method of identifying a combination of antibodies with a combined improved anti tumor activity the method comprising identifying at least two anti RTK antibodies capable of inducing synergistic endocytosis of said RTK in a cell expressing said RTK, thereby identifying the combination of antibodies with the combined improved anti-tumor activity.
A pharmaceutical composition comprising as an active ingredient at least two anti RTK antibodies capable of inducing synergistic endocytosis of said RTK in a cell expressing said RTK and a pharmaceutically acceptable carrier of diluent.
An article-of-manufacturing comprising a packaging material and a pharmaceutical composition identified for treating cancer being contained within said packaging material, said pharmaceutical composition comprising as an active ingredient at least two anti RTK antibodies capable of inducing synergistic endocytosis of said RTK in a cell expressing said RTK.
A method of treating cancer in a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of at least two anti RTK antibodies capable of inducing synergistic endocytosis of said RTK in a cell expressing said RTK, thereby treating cancer in the subject.
Dependencies are inferred from the claim text.