Continuous flow chamber device for separation, concentration, and/or purfication of cells
OwnerMichael King, Nichola Charles +5inventors
InventorsMichael King, Nichola Charles, Jane Liesveld, John Gentile, Kuldeepsinh Rana, Nathan Clark, Nipa Mody
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
Claims17
A method for separating, concentrating, and/or purifying a particular cell type from a mixture of cells comprising the steps of
- providing a flow surface containing an adhesive molecule that selectively binds with the particular cell type;
- and
- flowing the mixture of cells on the flow surface.
An implantable device for neutralizing tumor cells comprising a flow chamber, wherein a wall of the chamber contains an adhesive molecule that selectively binds with the tumor cells and a molecule that neutralizes the cancer cells.
A method for neutralizing tumor cells comprising the steps of
- providing a flow surface containing an adhesive molecule that selectively binds with the tumor cells and a molecule that neutralizes the cancer cells;
- and
- flowing the tumor cells on the flow surface.
Dependencies are inferred from the claim text.