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AssigneeKeio University
InventorsJin Nakahara, Hiroaki Asou, Sadakazu Aiso
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The present invention provides pharmaceutical compositions composing, as an active ingredient, a substance capable of activating the γ chain of Fc receptors (FcRγ) (provided that the substance is not an immunoglobulin for intravenous injection), and agents for stimulating myelinogenesis. The invention also provides agents for stimulating the differentiation of oligodendroglial precursor cells, agents for activating Fyn tyrosine kinase, and agents for stimulating the expression of myelin basic protein, all comprising a substance capable of activating FcRγ as an active ingredient. Further, the invention provides a method of detecting myelinogenetic oligodendroglias or precursor cells thereof which comprises using the expression of FcRγ in oligodendroglias or precursor cells thereof as an indicator.
1-32. (canceled)
A method for treating at least one disease selected from the group consisting of demyelinating disease, dysmyelinating disease, myelinoclasis, and combinations thereof, in a mammal in need thereof, comprising, administering a substance capable activating the γ chain of at least one Fc receptor (FcRγ) to the mammal, in an amount sufficient to treat the at least one disease.
Dependencies are inferred from the claim text.