Stabilized single domain antibodies
AssigneeAblynx N.V.
InventorsKaren Silence, Marc Lauwereys, Torsten Dreier
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Abstract
The present invention relates to heterospecific polypeptide constructs comprising at least one single domain antibody directed against a therapeutic and/or diagnostic target and at least one single domain antibody directed against a serum protein, said construct having a prolonged lifetime in biological circulatory systems. The invention further relates to methods for stabilising VHHs in biological circulatory systems.
Claims64
A polypeptide construct comprising:
- at least one single domain antibody directed against a therapeutic and/or diagnostic target, and
- at least one single domain antibody directed against a serum protein.
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A method for prolonging the half-life of a single domain antibody in the blood stream of a subject, said antibody directed against a therapeutic and/or diagnostic target, comprising joining thereto one or more single domain antibodies directed against a serum protein.
Dependencies are inferred from the claim text.