Combination therapy for treating protein deficiency disorders
OwnerJian-Qiang Faninventor
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Abstract
This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.
Claims20
A method of extending the half-life and prolonging the activity in vivo of a purified protein in an individual who has been administered the protein in a pharmaceutically acceptable carrier, which method comprises contacting the protein with an effective amount of an active site-specific chaperone in a pharmaceutically acceptable carrier.
A method for improving treatment of an individual who has a disorder characterized by a protein deficiency and who is being administered a purified replacement protein, comprising co-administering to the individual an effective amount of an active site-specific chaperone for the replacement protein.
Dependencies are inferred from the claim text.