Method for in vitro preconditioning of myoblasts before transplantation
OwnerJacques Tremblayinventor
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Abstract
Methods of pretreating healthy donor's myoblast cultures with growth or trophic factors on transplantation into subjects suffering from myopathic conditions such as muscular dystrophy. Compositions comprising myoblasts and fusion-promoting metalloproteases can be transplanted. Alternatively, myoblasts can be transplanted along with an agent inducing the expression of a fusion-promoting metalloprotease, or a composition comprising genetically-modified myoblasts capable of expressing a fusion-promoting metalloprotease can be transplanted.
Claims6
A method for increasing the number of transplanted myoblasts which migrate into a recipient muscle tissue and which fuse either with the myoblasts or muscle fibers of said recipient muscle tissue, said method comprising transplanting into a patient affected by a recessive myopathy a composition comprising myoblasts transformed with a gene construct capable of expressing a metalloprotease involved in extracellular matrix destruction.
Dependencies are inferred from the claim text.