Method for inducing differentiation of regulatory t cells usinggip-anchored protein agonist and pharmaceutical composition therefor ( as amended
AssigneeKirin Beer Kabushiki Kaisha
InventorTomoko Watanabe
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Abstract
An object of the present invention is to provide a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells, an immunosuppressive method using these methods, and pharmaceutical compositions for use in these methods. Furthermore, a method for inducing the differentiation of and/or promoting the proliferation of regulatory T cells and a method for immunosuppression using such methods are provided, which involve causing an agonist of a GIP anchored protein to act on T cells expressing the GIP anchored protein.
Claims35
A method for inducing the differentiation of a regulatory T cell and/or promoting the proliferation of a regulatory T cell, which comprises stimulating a GPI-anchored protein existing on the surface of an immunocyte other than CD52 with an agonist of the protein.
A method for preparing a humanized antibody or an antibody against a GPI-anchored protein other than CD52, which is a drug having effects of inducing the differentiation of a regulatory T cell and/or promoting the proliferation of a regulatory T cell.
A method for screening for a drug having the effects of inducing the differentiation of and/or promoting the proliferation of a regulatory T cell using as an index the interaction with a GPI-anchored protein other than CD52, which comprises causing a cell expressing a GPI-anchored protein other than CD52 to come into contact with a candidate compound and then detecting their interaction or a response of the GPI-anchored protein to stimulation.
A regulatory T cell derived from a human immunocyte, which is obtained by stimulating an immunocyte collected from a patient's body or another human's body, specifically by stimulating a GPI-anchored protein existing on the surface of the immunocyte, other than CD52, with an agonist of the protein, so as to induce differentiation into a regulatory T cell and to promote the proliferation of the regulatory T cell.
A method for producing a regulatory T cell derived from a human immunocyte, which comprises stimulating an immunocyte collected from a patient's body or another human's body, specifically by stimulating a GPI-anchored protein existing on the surface of the immunocyte, other than CD52, with an agonist of the protein, so as to induce the differentiation into a regulatory T cell and promote the proliferation of the regulatory T cell.
A pharmaceutical composition for inducing the differentiation of and/or promoting the proliferation of a regulatory T cell, which contains an agonist of a GPI-anchored protein other than CD52 as an active ingredient.
Dependencies are inferred from the claim text.