Stem-cell, precursor cell, or target cell-based treatment of multiorgan failure and renal dysfunction
AssigneesUniversity of Utah Research Foundation, United States of America Department of Veterans Affairs
InventorChristof Westenfelder
Life of this patent
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Abstract
Methods for the treatment of acute renal failure, multi-organ failure, early dysfunction of kidney transplant, chronic renal failure, organ dysfunction, and wound healing are provided. The methods include delivering a therapeutic amount of hematopoietic stem cells, non-hematopoietic, mesenchymal stem cells, hemangioblasts, and pre-differentiated cells to a patient in need thereof.
Claims33
A method of treating multi-organ failure, kidney dysfunction, or wound healing, said method comprising delivering a therapeutic amount of stem cells to a patient in need thereof.
A method of treating multi-organ failure, kidney dysfunction, wound healing or organ dysfunction comprising delivering a therapeutic amount of a stimulant of stem cell mobilization to a patient in need thereof;
- wherein the stimulant mobilizes stem cells to the organs in need thereof.
A method of treating organ dysfunction, said method comprising delivering a therapeutic amount of pre-differentiated stem cells to a patient in need thereof;
- wherein said cells are pre-differentiated in vitro into organ specific cells.
A method of treating organ dysfunction, said method comprising delivering a therapeutic amount of hemangioblasts to a patient in need thereof.
23-44. (canceled)
A method of treating multi-organ failure, kidney dysfunction, organ dysfunction, or wound healing, said method comprising delivering a therapeutic amount of a mixture hematopoietic stem cells and mesenchymal stem cells to a patient in need thereof.
A composition for the treatment of multi-organ failure, organ dysfunction, or wound healing, said composition comprising a therapeutic amount of hematopoietic stem cells and mesenchymal stem cells.
The composition of 51 wherein a ratio of said hematopoietic stem cells to said mesenchymal stem cells is optimized for the treatment of kidney dysfunction or other organ dysfunction.
54-59. (canceled)
Dependencies are inferred from the claim text.