Oral antimicrobial composition
OwnerMadhyastha Srinivasa, Karen LoVetriinventors
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Abstract
The present invention includes compositions and methods for inhibiting the growth and formation of biofilms. The compositions and methods can employ antimicrobial compounds and/or antimicrobial peptides. In an embodiment, a composition includes a combination of at least one antimicrobial compound and at least one CSP analogue or CSP. In an embodiment, a method to inhibit the growth and/or formation of an oral biofilm includes administering a composition comprising at least one antimicrobial compound and at least one CSP analogue or CSP.
Claims42
A composition comprising:
- a) at least one peptide of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, and SEQ ID NO:
- 11;
- and
- b) one or more antimicrobial agents comprising a benzimidazole, a polyol, a polyphenol, an antiseptic, an antibiotic, a bacteriocin, a citrate, an anti-caries agent, a triterpenoid, or chitosan.
A method of inhibiting an oral biofilm comprising:
- administering a composition comprising at least one peptide of (a) SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, and SEQ ID NO:
- 11;
- and (b) at least one of a benzimidazole, a polyol, a polyphenol, an antiseptic, an antibiotic, a bacteriocin, a citrate, an anti-caries agent, a triterpenoid, and chitosan.
A method of inhibiting an oral biofilm comprising:
- administering a therapeutically effective amount for treating a condition caused by dental plaque associated Streptococcus mutans of a composition comprising at least one peptide of (a) SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, and SEQ ID NO:
- 11;
- and (b) at least one of a benzimidazole, a polyol, a polyphenol, an antiseptic, an antibiotic, a bacteriocin, a citrate, an anti-caries agent, a triterpenoid, and chitosan.
Dependencies are inferred from the claim text.