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AssigneeThe Wistar Institute of Anatomy and Biology
InventorsThanos Halazonetis, Linda Schultz
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A method for detecting DNA damage in a tissue sample involves contacting an immobilized biological sample with a labeled ligand which binds to human 53Bp1, and examining the immobilized sample for the presence of a label generated-detectable signal concentrated in foci in said sample. The presence of concentrated foci is indicative of DNA damage and the presence of diffuse signal is indicative of a normal sample. Diagnostic reagents contain a ligand that binds to human 53Bp1 associated with a detectable label. Diagnostic kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. Compositions that inhibit or antagonize the biological activity of 53Bp1 are identified by suitable assays, and are employed in methods of retarding the growth of a cancer cell.
A method for detecting DNA damage in a tissue sample, comprising:
A diagnostic reagent comprising a ligand that binds to human 53Bp1, said ligand associated with a detectable label.
A composition that antagonizes or inhibits the biological activity or expression of 53Bp1, or binds to 53Bp1.
A method of targeting a tumor cell for delivery of a therapeutic agent, comprising administering to a patient bearing a tumor containing 53Bp1 foci a ligand that binds to 53Bp1, said ligand associated with a compound that retards the growth of, or kills, said tumor cell.
Dependencies are inferred from the claim text.