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US 2007/0178012 A1Published application
Side view imaging microwell array
OwnerAnthony Ferrante, David Rosen +1inventors
InventorsAnthony Ferrante, David Rosen, R. Daniel Ferguson
Life of this patent
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Abstract
Methods and apparatus for imaging a sample using a microwell array are provided. The methods and apparatus allow side view imaging of a sample to acquire fluorescence or bright field images.
Claims35
An apparatus for imaging a sample comprising
- a substrate defining a well for holding the sample, the well comprising a bottom and a first wall;
- and
- a first optical surface adjacent the first wall of the well, the first optical surface directing radiation from the well to an imaging lens located below the substrate.
An apparatus for imaging a sample comprising:
- a substrate defining a rectangular well for holding the sample, the well comprising a bottom, a first wall, and a second wall;
- a first optical surface adjacent the first wall of the well, the first optical surface receiving incident radiation and directing the incident radiation through the first wall of the well;
- a second optical surface adjacent the second wall of the well, the second optical surface receiving radiation from the well and direct the radiation from the well to an imaging lens located below the substrate, and
- an upper portion of the substrate defining a tapered hole positionable over the well.
1 more element
An apparatus for imaging a sample comprising:
- a substrate defining a well for holding the sample;
- means for directing incident radiation to the sample through a wall of the well;
- and
- means for receiving radiation reflected or emitted by the sample to form an image of the sample.
1 more element
A method of imaging a sample comprising:
- providing a substrate defining a well for holding the sample, the well comprising a bottom, a first wall, and a first optical surface, the first optical surface being adjacent the first wall and adapted to direct radiation from the well to an imaging lens located below the substrate;
- directing incident radiation into the well, and
- receiving radiation reflected or emitted by the sample into the imaging lens to form an image of the sample.
A method of imaging a sample comprising:
- directing incident radiation to a sample in a well of a substrate;
- receiving radiation reflected or emitted by the sample through a wall of the well, and
- directing the reflected or emitted radiation via an optical surface formed in the substrate to an imaging lens to form an image of the sample.
An apparatus for imaging a sample comprising
- a substrate defining a well for holding the sample, the well comprising a bottom and a first wall;
- and
- a first channel adjacent the first wall of the well, the first channel capable of receiving a turning optic capable of directing radiation from the well to an imaging lens located below the substrate.
Dependencies are inferred from the claim text.