Instrumentation and method for optical measurement of samples

An optical measurement instrument for measuring samples, comprising

• an illumination source (511) for excitation or activation of a sample (581),
• a point detector (531) for measuring emission radiation in a first measurement mode, wherein the point detector outputs a signal corresponding to the radiation received within the whole sensor area of the point detector, and
• means (563, 551, 552, 534, 535) for projecting emission radiation from a first measurement volume of a sample to the point detector,
• wherein the point detector outputs a signal which corresponds to intensity of the emission radiation received from the whole first measurement volume, characterized in that the instrument further comprises
• an image detector (591) for measuring emission radiation in a second measurement mode, wherein a sensor area of the image detector includes a multitude of sensor pixels for providing signals which correspond to the radiation received by said sensor pixels, and
• means (563, 551, 552, 594, 595) for projecting emission radiation from a second measurement volume of a sample to the sensor area of the image detector,
• wherein the image detector (591) outputs a signal including information on intensity and spatial distribution of the emission radiation received from details within the second measurement volume of a sample.