Thermally Insulated Apparatus for Liquid Chromatographic Analysis
AssigneeAmgen Inc.
InventorsMorlan Lunsford, Julian Osaki, Glen Salle, Christopher Corpuz
Life of this patent
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Abstract
A thermally insulated apparatus provides a substantially adiabatic environment for elevated temperature liquid chromatography applications. The thermally insulated apparatus minimizes or eliminates temperature gradients between columns and mobile phases, and maintains a temperature at or near the set point of an operably coupled heating means. The apparatus is also effective when used in conjunction with a liquid mobile phase heater such as those provided by an HPLC column compartment or a metal capillary of sufficient length to heat the liquid mobile phase.
Claims16
A thermally insulated apparatus comprising:
- (a) an elongated metallic body having a hollow interior portion and two openings located at opposing ends of a longitudinal axis;
- (b) an insulating material contacting the elongated metallic body of (a);
- and
- (c) two capping members having a design that allows the capping members to substantially cover the openings located at opposing ends of the longitudinal axis of the metallic body of (a), and
- wherein each of the two capping members comprise an opening or slit that allows tubing, which carries mobile phase into and out of a analytical separation column, to pass therethrough.
A thermally insulated apparatus comprising:
- (a) an elongated, cylindrical copper tube having a hollow interior portion and two openings located at opposing ends of a longitudinal axis;
- (b) a polyethylene foam insulating material contacting the outer surface of the copper tube of (a), wherein the polyethylene foam is removed from portions of the outer surface of the copper tube in areas that contact a heating source;
- and
- (c) two capping members having a design that allows the capping members to substantially cover the openings located at opposing ends of the longitudinal axis of the metallic cylindrical tube of (a), and
- wherein each of the two capping members comprise an opening or slit that allows tubing, which carries mobile phase into and out of the analytical separation column, to pass therethrough;
- wherein the thermally insulated apparatus has a size that allows it to fit within the column compartment of an Agilent 1100 or an Agilent 1200 liquid chromatography system.
Dependencies are inferred from the claim text.