Calibration of Sensors or Measuring Systems

A method for calibrating continuously measuring sensors or automatic measuring systems for glucose in the interstitium, wherein, to compensate a physiologically conditioned deviation in a glucose content between a location of a reference measurement and a location of the sensor measurement, a trend signal of a glucose value is used as additional information in a calibration of the measuring system or sensor.

A measuring system or sensor for carrying out a calibration method comprising the steps of setting a gradient of a measuring curve and a standard offset prior to use, and adapting the offset during use by a one-point calibration with the aid of a reference measurement.

A measuring system or sensor for carrying out a calibration method, wherein, to compensate a physiologically conditioned deviation in a glucose content between a location of a reference measurement and a location of a sensor measurement, a trend signal of a glucose value is used as additional information in the calibration of the measuring system or sensor.

A measuring system for determining a value of a biochemical parameter, the measuring system comprising:

• a) a measuring sensor (2, Rm, Rref), having a known gradient and a known offset, for recording a measured value in vivo in a temporally sequential or continuous fashion, and outputting measuring sensor values (P1, P2), the measured values of the measured variable or formed from the measured values, and
• b) a data acquisition device that receives the measuring sensor values and at least one reference value and forms characteristic values of the parameter from the measuring sensor values, wherein
• c) for the purpose of an automatic self-calibration of the measuring system, the data acquisition device compares one of the characteristic values with the at least one reference value or a value calculated therefrom, and the offset of the measuring sensor is adjusted in accordance with the result of the comparison by a one-point calibration.