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AssigneeOsteotech, Inc.
InventorsJean Edwards, Lawrence Shimp, Michele Diegmann, Todd Boyce, Nelson Scarborough, James Russell
Estimating the term…
A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
1-54. (canceled)
A load-bearing osteoinductive osteoimplant comprising monolithic section of rigid bone having a height that decreases along a length of the bone such that the section of bone is ramp-shaped, said bone comprising at least one outer surface demineralized zone, said bone further comprising a non-demineralized core region proximate to and beneath the at least one outer surface demineralized zone, wherein said non-demineralized core region is defined in at least two directions by the at least one outer surface demineralized zone.
A load-bearing osteoinductive osteoimplant comprising monolithic section of rigid bone having a height that decreases along a length of the bone such that the section of bone is ramp-shaped, wherein at least one outer surface of the ramp-shaped bone comprises a series of steps, said at least one outer surface comprising an outer surface demineralized zone, said bone further comprising a non-demineralized core region proximate to and beneath the at least one outer surface demineralized zone, wherein said non-demineralized core region is defined in at least two directions by the at least one outer surface demineralized zone.
A load-bearing osteoinductive osteoimplant comprising monolithic section of rigid bone having a height that decreases along a length of the bone such that the section of bone is ramp-shaped, wherein at least one outer surface of the ramp-shaped bone comprises a plurality of triangular protrusions, said at least one outer surface comprising an outer surface demineralized zone, said bone further comprising a non-demineralized core region proximate to and beneath the at least one outer surface demineralized zone, wherein said non-demineralized core region is defined in at least two directions by the at least one outer surface demineralized zone.
A load-bearing osteoinductive osteoimplant comprising monolithic section of rigid bone having a first side and a second side substantially parallel to the first side, said bone comprising at least one outer surface demineralized zone, said bone further comprising a non-demineralized core region proximate to and beneath the at least one outer surface demineralized zone, wherein said non-demineralized core region is defined in at least two directions by the at least one outer surface demineralized zone.
Dependencies are inferred from the claim text.