Porous three dimensional nest scaffolding

A scaffold for location in a patient, the scaffold comprising:

• a non-woven substrate;
• at least one non-woven nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume;
• and
• a bioactive agent disposed within the enclosed volume on the substrate.

A device for delivery of a bioactive agent to a vessel of a patient, the device comprising:

• a substrate;
• at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume;
• and
• a bioactive agent disposed within the enclosed volume on the substrate,
• wherein the device is a nanoscale device.

A radially expandable lumenal scaffold comprising:

• a deformable substrate;
• at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume;
• and
• a bioactive agent disposed within the enclosed volume on the substrate,
• wherein the substrate is wrapped about an axis to form the scaffold.

A radially expandable lumenal scaffold comprising:

• a deformable substrate;
• at least one nest connected to the substrate, the nest extending away from the substrate to define an enclosed volume on the substrate associated with the nest, the nest having openings that extend from an outer surface of the nest to the associated enclosed volume;
• and
• a bioactive agent disposed within the enclosed volume on the substrate,
• wherein the substrate is folded to form the scaffold.