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US 2007/0167984 A1Published application
Method and apparatus for stimulation of baroreceptors
AssigneeCVRx, Inc.
InventorsRobert Kieval, Matthew Burns, Peter Keith, David Serdar, Martin Rossing
Life of this patent
Estimating the term…
Abstract
Devices and methods for controlling the baroreflex system for the treatment and/or management of cardiovascular, renal, and neurological disorders.
Claims138
A baroreflex stimulator, comprising:
- a pulse generator to provide a baroreflex stimulation signal through an electrode;
- and
- a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template.
A baroreflex stimulator, comprising:
- a pulse generator to provide a baroreflex stimulation signal through an electrode;
- and
- means for modulating the baroreflex stimulation signal based on a circadian rhythm template.
A method for operating an implantable medical device, comprising:
- applying a baroreflex stimulation therapy using a baroreflex stimulator in the implantable medical device;
- and
- modulating the baroreflex stimulation therapy based on a circadian rhythm template.
A baroreflex stimulator, comprising:
- a driver adapted to provide a control signal through a baroreceptor activation device;
- and
- a controller to periodically modulate the control signal based on an algorithm.
A baroreflex stimulator, comprising:
- a driver adapted to provide a control signal through a baroreceptor activation device;
- and
- means for periodically modulating the control signal based on an algorithm.
A method for operating an implantable medical device, comprising:
- applying a baroreflex stimulation therapy using a baroreceptor activation device in the implantable medical device;
- and
- periodically modulating the baroreflex stimulation therapy based on an algorithm.
An implantable medical system, comprising:
- a baroreflex stimulator to apply a baroreflex stimulation signal through an electrode;
- a myocardial infarction detector to detect an event indicative of myocardial infarction;
- and
- a controller connected to the baroreflex stimulator and to the myocardial infarction detector, the controller adapted to apply a baroreflex therapy in response to a detected event indicative of myocardial infarction.
1 more element
An implantable medical system, comprising:
- means for detecting a myocardial infarction;
- and
- means for applying baroreflex therapy to a pressoreceptive region to decrease coronary vascular resistance and increase blood flow in response to detecting the myocardial infarction.
A method, comprising:
- detecting an event corresponding to a myocardial infarction;
- and
- in response to a detected event corresponding to a myocardial infarction, applying a baroreflex therapy using an electrode positioned proximate to a baroreflex neural target.
An implantable medical system, comprising:
- a baroreflex stimulator to apply a baroreflex stimulation signal to an electrode;
- a sensor to detect a parameter indicative of heart failure;
- and
- a control system connected to the baroreflex stimulator and to the sensor, the control system adapted to apply a baroreflex therapy in response to a detected parameter indicative of heart failure.
1 more element
An implantable medical system, comprising:
- means for detecting a heart failure;
- and
- means for applying baroreflex therapy to a baroreceptor region to regulate blood pressure and sympathetic nervous system activity.
A method, comprising:
- detecting a parameter corresponding to heart failure;
- and
- applying a baroreflex therapy using a baroreceptor activation device positioned adjacent a baroreceptor in response to detecting a parameter corresponding to heart failure.
A system for providing baroreflex stimulation, comprising:
- an adverse event detector to sense an adverse event and provide a signal indicative of the adverse event;
- and
- a baroreflex stimulator, including:
- a pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy;
- and a modulator to receive the signal indicative of the adverse event and modulate the baroreflex stimulation signal based on the signal indicative of the adverse event to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
2 more elements
A baroreflex stimulator, comprising:
- an implantable pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy;
- and
- means for modulating the baroreflex stimulation signal based on a signal indicative of an adverse event to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
A method for operating an implantable medical device, comprising:
- receiving a signal regarding a detected adverse event at a baroreceptor stimulator;
- performing a first baropacing therapy using the baroreceptor stimulator when the adverse event is not detected;
- and
- automatically performing a second baropacing therapy using the baroreceptor stimulator when the adverse event is detected.
1 more element
A system for providing baroreflex stimulation, comprising:
- a sensor to detect a parameter and provide a signal indicative of the parameter;
- and
- a baroreflex stimulator, including:
- a driver to provide a control signal adapted to deliver a baroreflex therapy;
- controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
2 more elements
A baroreflex stimulator, comprising:
- an implantable driver to provide a control signal adapted to provide a baroreflex therapy;
- and
- a controller to receive the signal indicative of the parameter and modulate the control signal based on the signal indicative of the parameter to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
A method for operating an implantable medical device, comprising:
- receiving a signal indicative of a parameter at a baroreceptor stimulator;
- performing a first baropacing therapy using the baroreceptor stimulator when the parameter is not detected;
- and
- performing a second baropacing therapy using the baroreceptor stimulator when the parameter is detected.
1 more element
A system for providing baroreflex stimulation, comprising:
- a heart rate monitor to sense a heart rate and provide a signal indicative of the heart rate;
- and a baroreflex stimulator, including:
- a pulse generator to intermittently generate a stimulation signal to provide baroreflex stimulation for a baroreflex therapy;
- and
- a modulator to adjust the stimulation signal based on the signal indicative of the heart rate such that the stimulation signal provides a desired baroreflex stimulation corresponding to a desired heart rate.
2 more elements
A system for providing baroreflex stimulation, comprising:
- a baroreflex stimulator, including:
- a pulse generator to generate a stimulation signal to provide intermittent baroreflex stimulation for a baroreflex therapy;
- and
- a modulator to adjust the stimulation signal;
- a cardiovascular parameter monitor to monitor at least one cardiovascular parameter and provide a first signal indicative of the cardiovascular parameter during the baroreflex stimulation and a second signal indicative of the cardiovascular parameter without the baroreflex stimulation;
- and
- a comparator to provide a detected change for the cardiovascular parameter based on the first and second signals, and to provide a therapy control signal based on a desired change for the cardiovascular parameter and the detected change.
4 more elements
A baroreflex stimulator, comprising:
- means for intermittently providing baroreflex stimulation for a baroreflex therapy over a period of time;
- means for comparing values for at least one cardiovascular feedback parameter when the baroreflex stimulation is applied and when then baroreflex stimulation is not applied to provide a detected feedback change;
- means for comparing the detected feedback change to a desired feedback change to provide a comparison result;
- and
- means for adjusting the baroreflex stimulation based on the comparison result to control the baroreflex therapy over the period of time.
2 more elements
A method, comprising:
- intermittently providing baroreflex stimulation for a baroreflex therapy over a period of time;
- comparing values for at least one cardiovascular feedback parameter when the baroreflex stimulation is applied and when then baroreflex stimulation is not applied to provide a detected feedback change;
- comparing the detected feedback change to a desired feedback change to provide a comparison result;
- and
- adjusting the baroreflex stimulation based on the comparison result to control the baroreflex therapy over the period of time.
2 more elements
A system for providing baroreceptor stimulation comprising:
- a sensor to sense a physiologic parameter and provide a signal indicative of the physiologic parameter;
- and
- a baroreceptor activation device, including a pulse generator to intermittently generate a stimulation signal to provide baroreceptor stimulation for a baroreflex therapy;
- and
- a control system to adjust the stimulation signal based on the signal indicative of the physiologic parameter such that the stimulation signal provides a desired baroreceptor stimulation corresponding to a desired physiologic parameter.
2 more elements
A system for providing baroreceptor stimulation, comprising:
- a baroreceptor activation device including:
- a pulse generator to generate a stimulation signal to provide intermittent baroreceptor stimulation for a baroreflex therapy;
- and
- a sensor to monitor at least one physiologic parameter and provide a first a signal indicative of the physiologic parameter during the baroreceptor stimulation and a second signal indicative of a threshold value of a physiologic parameter;
- a comparator to provide a detected change for the physiologic parameter based on the first and second signals, and to provide a therapy control signal based on the desired change for the physiologic parameter and the desired change.
2 more elements
A baroreceptor stimulator, comprising
- means for intermittently providing baroreceptor stimulation for a baroreflex for a baroreflex therapy over a period of time;
- means for comparing values for at least one physiologic parameter when the baroreceptor stimulation is applied and values indicative of a threshold value to provide a detected change in the physiologic parameter;
- means for comparing the detected physiologic parameter change to a desired physiologic parameter change to provide a comparison result;
- and
- means for adjusting the baroreceptor stimulation based on the comparison result to control the baroreflex therapy over a period of time.
2 more elements
A method, comprising:
- intermittently providing baroreceptor stimulation for a baroreflex therapy over a period of time;
- comparing values for at least one physiologic parameter when the baroreceptor stimulation is applied and values indicative of a threshold parameter to provide a detected physiologic parameter change;
- comparing the detected physiologic parameter change to a desired physiologic parameter change to provide a comparison result;
- and
- adjusting the baroreceptor stimulation based on the comparison result to control the baroreflex therapy over a period of time.
2 more elements
An implantable medical device, comprising:
- a pulse generator to generate baroreflex stimulation pulses;
- a sensor circuitry;
- a lead adapted to be electrically connected to the pulse generator and to the sensor circuitry, the lead including an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry;
- and
- a controller connected to the pulse generator and the sensor circuitry, the controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure.
2 more elements
An implantable medical device, comprising:
- means for delivering baroreflex therapy to a baroreflex neural target site using an intravascular lead and an electrode on the lead;
- means for monitoring blood pressure near the baroreflex neural target site using a pressure sensor on the lead;
- and
- means for adjusting the baroreflex therapy based on the blood pressure.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate baroreflex stimulation pulses;
- a sensor circuitry;
- a lead adapted to be electrically connected to the pulse generator and to the sensor circuitry, the lead including an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a sensor to provide a signal to the sensor circuitry that corresponds to a pre-ejection period measured between a sensed electrical event in a ventricle and onset of ventricular ejection derived from a pulmonary arterial blood pressure sensor;
- and
- a controller connected to the pulse generator and the sensor circuitry, the controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure.
2 more elements
A method, comprising:
- delivering baroreflex therapy to a baroreflex neural target site using an intravascular lead and an electrode on the lead;
- monitoring blood pressure near the baroreflex neural target site using a pressure sensor on the lead;
- and
- adjusting the baroreflex therapy based on the blood pressure.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate baroreceptor stimulation pulses;
- a sensor circuitry;
- a lead adapted to be electrically connected to the pulse generator and to the sensor circuitry, the lead including an electrode to distribute the baroreceptor stimulation pulses to a baroreceptor site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry;
- and
- a controller connected to the pulse generator and the sensor circuitry, the controller adapted to adjust the baroreceptor stimulation pulses based on the blood pressure.
2 more elements
An implantable medical device, comprising:
- means for delivering baroreflex therapy to a barorecetor neural target site using an intravascular lead and an electrode on the lead;
- means for monitoring blood pressure near the baroreceptor neural target site using a pressure sensor on the lead;
- and
- means for adjusting the baroreflex therapy based on the blood pressure.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate baroreceptor stimulation pulses;
- a sensor circuitry;
- a lead adapted to be electrically connected to the pulse generator and to the sensor circuitry, the lead including an electrode to distribute the baroreceptor stimulation pulses to a baroreceptor site and
- a sensor to provide a signal to the sensor circuitry that includes a measure of blood pressure and corresponds to a specific physiologic event;
- and
- a controller connected to the pulse generator and the sensor circuitry, the controller adapted to adjust the baroreceptor stimulation pulses based on the blood pressure.
3 more elements
A method, comprising:
- delivering baroreflex therapy to a baroreceptor neural target site using an intravascular lead and an electrode on the lead;
- monitoring blood pressure near the baroreceptor neural target site using a pressure sensor on the lead;
- and
- adjusting the baroreflex therapy based on the blood pressure.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate a baroreflex stimulation signal as part of a baroreflex therapy;
- a lead to be electrically connected to the pulse generator and to be intravascularly fed into a heart, the lead including an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart;
- a sensor to sense a physiological parameter regarding an efficacy of the baroreflex therapy and to provide a signal indicative of the efficacy of the baroreflex therapy;
- and
- a controller connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy.
2 more elements
An implantable baroreflex stimulator, comprising:
- means for delivering baroreflex therapy through a lead intravascularly fed through at least a portion of the heart to a baroreceptor region proximate to a heart to inhibit sympathetic activity;
- and
- means for providing feedback regarding an efficacy of the baroreflex therapy for use to control delivery of the baroreflex therapy.
A method, comprising:
- applying baroreflex therapy, including electrically stimulating a baroreceptor region in or near a heart using a lead intravascularly fed into at least a portion of the heart;
- sensing a physiologic parameter indicative of an efficacy of the baroreflex therapy;
- and
- modifying the baroreflex therapy based on the physiological parameter.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate a baroreflex stimulation signal as part of a baroreflex therapy;
- a lead to be electrically connected to the pulse generator, the lead including an electrode to deliver the baroreflex signal to a baroreflex neural target;
- a sensor to sense a physiological parameter regarding an efficacy of the baroreflex therapy and to provide a signal indicative of the efficacy of the baroreflex therapy;
- and
- a controller connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy.
2 more elements
A method, comprising:
- applying baroreflex therapy, including electrically stimulating a baroreceptor region using a lead with an electrode;
- sensing a physiologic parameter indicative of an efficacy of the baroreflex therapy;
- and
- modifying the baroreflex therapy based on the physiological parameter.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate a baroreceptor stimulation signal as part of a baroreflex therapy;
- a lead to be electrically connected to the pulse generator and to be intravascularly fed into a heart, the lead including an electrode to be positioned in or proximate to the heart to deliver the baroreceptor signal to a baroreceptor region in or proximate to the heart;
- a sensor to sense a physiological parameter regarding the need to modify the baroreflex system and to provide a signal indicative of the need to modify the baroreflex system;
- and
- a controller connected to the pulse generator to control the baroreceptor stimulation signal and to the sensor to receive the signal indicative of the need to modify the baroreflex system.
2 more elements
An implantable baroreflex stimulator, comprising:
- means for delivering baroreflex therapy through a lead intravascularly fed through at least a portion of the heart to a baroreceptor region proximate to a heart to inhibit sympathetic activity;
- and
- means for providing feedback regarding an efficacy of the baroreflex therapy for use to control delivery of the baroreflex therapy.
A method, comprising:
- applying baroreflex therapy, including electrically stimulating a baroreceptor region in or near a heart using a lead intravascularly fed into at least a portion of the heart;
- sensing a physiologic parameter indicative of the need to modify the baroreflex system;
- and
- modifying the baroreflex therapy based on the physiological parameter.
1 more element
An implantable medical device, comprising:
- a pulse generator to generate a baroreceptor stimulation signal as part of a baroreflex therapy;
- a lead to be electrically connected to the pulse generator, the lead including an electrode to deliver the baroreceptor signal to a baroreceptor neural target;
- a sensor to sense a physiological parameter and to provide a signal indicative of the need to modify the baroreflex system;
- and
- a controller connected to the pulse generator to control the baroreceptor stimulation signal and to the sensor to receive the signal indicative of the need to modify the baroreflex system.
2 more elements
A system for providing baroreflex stimulation, comprising:
- a cardiac activity monitor to sense cardiac activity and provide a signal indicative of the cardiac activity;
- and
- a baroreflex stimulator, including:
- a pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy;
- and
- a modulator to receive the signal indicative of the cardiac activity and modulate the baroreflex stimulation signal based on the signal indicative of the cardiac activity to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
3 more elements
A baroreflex stimulator, comprising:
- an implantable pulse generator to provide a baroreflex stimulation signal adapted to provide a baroreflex therapy;
- and means for modulating the baroreflex stimulation signal based on a signal indicative of cardiac activity to change the baroreflex therapy from a first baroreflex therapy to a second baroreflex therapy.
A method for operating an implantable medical device, comprising:
- receiving a signal regarding an activity level;
- and
- setting a baroreflex stimulation level for a baroreflex stimulator of the device based on the signal regarding the activity level.
A method, comprising:
- determining an activity level;
- setting a baroreflex stimulation level based on the activity level;
- and
- applying baroreflex stimulation at the baroreflex stimulation level.
1 more element
A system for providing baroreceptor stimulation, comprising:
- a sensor to sense a physiologic parameter and provide a signal indicative of the physiologic parameter;
- and
- a baroreceptor stimulator, including:
- a pulse generator to provide a baroreceptor stimulation signal adapted to provide a baroreflex therapy;
- and
- a control system to receive the signal indicative of the physiologic parameter and modify the baroreceptor stimulation signal based on the signal indicative of the physiologic parameter.
3 more elements
A baroreceptor stimulator, comprising:
- an implantable pulse generator to provide a baroreceptor stimulation signal adapted to provide a baroreflex therapy;
- and
- means for modulating the baroreceptor stimulation signal based on a signal indicative of a physiologic parameter to modify the baroreflex therapy.
Dependencies are inferred from the claim text.