Local concentration management system

A drug delivery device comprising:

• an elongate body defining a lumen and a delivery outlet, wherein said lumen and delivery outlet are in fluid communication;
• and
• a diffuser element secured to an outside portion of the elongate body and in fluid communication with the delivery outlet;
• wherein flow of a formulation through the lumen, through the delivery outlet, and through the diffuser element provides for diffusion of the formulation over an area defined by the diffuser element.

A method for delivery of a drug to a delivery site in a subject, the method comprising the steps of:

• implanting at the delivery site of a subject a drug delivery device comprising:
• an elongate body defining a reservoir containing a drug formulation, a lumen, and a delivery outlet, wherein said lumen and delivery outlet are in fluid communication with a reservoir;
• and
• a diffuser element secured to an outside portion of the elongate body and in fluid communication with the delivery outlet;
• wherein flow of the drug formulation from the reservoir, through the lumen, through the delivery outlet, and through the diffuser element provides for diffusion of the drug formulation over an area defined by the diffuser element.