Multi modal spectroscopy
AssigneeMassachusetts Institute of Technology
InventorsObrad Scepanovic, Joseph Gardecki, Michael Feld
Life of this patent
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Abstract
The present invention relates to multimodal spectroscopy (MMS) as a clinical tool for the in vivo diagnosis of disease in humans. The MMS technology combines Raman and fluorescence spectroscopy. A preferred embodiment involves diagnosis cancer of the breast and of vulnerable atherosclerotic plaque, esophageal, colon, cervical and bladder cancer. MMS is used to provide a more comprehensive picture of the metabolic, biochemical and morphological state of a tissue than afforded by either Raman or fluorescence and reflectance spectroscopies alone.
Claims62
A system for spectroscopic measurement of tissue comprising:
- a light source providing light for Raman and fluorescence collection;
- a probe that delivers light onto tissue;
- and
- a detector that detects Raman and fluorescent light from the tissue.
A system for-spectroscopic measurement of tissue comprising:
- a light source providing light for Raman and reflectance collection;
- a probe that delivers light onto tissue;
- and
- a detector that detects Raman and reflected light from the tissue.
A method for spectroscopic measurement of a material comprising:
- providing a light source system for Raman and fluorescence excitation light;
- illuminating a material with light from the light source system;
- and detecting Raman and fluorescent light from the material.
A method for spectroscopic measurement of a material comprising:
- providing a light source for Raman and reflectance light delivery;
- illuminating the material with light;
- and
- detecting Raman and reflected light from the material.
Dependencies are inferred from the claim text.