Platinum (II) complexes, preparation and use
AssigneePlatco Technologies (Proprietary) Limited
InventorJan Gysbert Du Preez
Life of this patent
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Abstract
The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.
Claims55
A method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, the method including the step of reacting a bis-dicarboxylatoplatinate(II) species with a neutral bidentate ligand to form a neutral dicarboxylatoplatinum(II) complex product containing a neutral bidentate ligand;
- and, if necessary, recrystallising the product to form a pure dicarboxylatoplatinum(II) complex containing a neutral bidentate ligand.
The method according to any one of the preceding claims wherein dicarboxylatoplatinate(II) species contaminating the product are removed from the product by dissolving the product in distilled water and adding an oxalate which transforms the dicarboxylatoplatinate(II) species into a species that can be separated from the dissolved product by filtration.
The method according to any one of the preceding claims, wherein the neutral bidentate ligand is an amine.
An oxalatoplatinum(II) complex containing an S or Se donor atom or atoms.
Oxalato(1-methyl-2-methylthioethylimidazole)platinum(II).
Oxalato(1-methyl-2-methylthiopropylimidazole)platinum(II).
Oxalato(1-butyl-2-methylthiomethylimidazole)platinum(II).
Oxalato(1-methyl-2-methylthiomethylimidazole)platinum(II).
Oxalato(1-butyl-2-methylthioethyimidazole)platinum(II).
Oxalato(2-methylthiomethylpyridine)platinum(II).
Oxalato(1-amino-2-thioethylethane)platinum (II).
Oxalato(1-amino-2-thiopropylethane)platinum (II).
Oxalato(1-amino-2-thiomethylethane)platinum(II).
Oxalato(1-amino-2-thioethylethane)platinum(II).
Oxalato(2,5-dithiahexane)platinum(II).
Oxalato(2,5-diseleno hexane)platinum(II).
An oxalatoplatinum(II) complex containing no traces of silver.
A method for producing a bis-dicarboxylatoplatnate(II) species, the method including the step of either reacting a platinum(II) compound or reacting a platinum(IV) compound with a dicarboxylate at a high mole ratio of greater than 1:4.
Dependencies are inferred from the claim text.