Improved process for the asymmetric synthesis of duloxetine
AssigneeEli Lilly and Company
InventorsMark Butchko, Alain Merschaert, Kenneth Moder
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Abstract
This invention provides an improved asymmetric process for the synthesis of duloxetine involving arylation of Compounds of Formula I.
Claims12
A process for preparing (+)-N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine comprising reacting (S)-3-Methylamino-1-(2-thienyl)-1-propanol with potassium hydroxide, and 1-fluoronaphthalene in an organic solvent or mixture of organic solvents.
A process for preparing (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine comprising reacting (S)-(−)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropanamine with potassium hydroxide and 1-fluoronaphthalene in an organic solvent or mixture of organic solvents.
Dependencies are inferred from the claim text.