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US 2007/0167634 A1Published application
Method for preparing irbesartan and intermediates thereof
AssigneeBristol-Myers Squibb Company
InventorsEdgar Miranda, Cornelis Vlaar, Jingyang Zhu
Life of this patent
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Abstract
A method for preparing irbesartan and intermediates thereof. Irbesartan has the structure of formula I,
Claims4
1 to 22. (canceled)
A method for preparing a compound of formula II in substantially pure form,
- comprising:
- (a) crystallizing a crude compound of formula II with at least one solvent selected from methyl tert-butyl ether and iso-propanol to give a compound of formula II in crystal form;
- (b) washing the compound of formula II in crystal form from step (a) with at least one solvent selected from methyl tert-butyl ether and iso-propanol to give the compound of formula II in substantially pure form;
- and
- (c) recycling the washed solvent collected from step (b) to crystallize a crude compound of formula II in the next batch as recited in step (a).
2 more elements
Dependencies are inferred from the claim text.