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US 2007/0167629 A1Published application
Processes for making pioglitazone and compounds of the processes
AssigneeSynthon IP Inc.
InventorsJie Zhu, Lambertus Thijs
Life of this patent
Estimating the term…
Abstract
Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
Claims20
A compound of formula (7), (8), or (15)
- wherein R represents a C1-C4 alkyl group or an optionally substituted phenyl group and R1 is C1-C4 alkyl group.
In a process for making pioglitazone, the improvement for which comprises forming a compound of formula (7) via a Darzens Condensation reaction
- wherein R1 is C1-C4 alkyl group, and converting said compound of formula (7) to pioglitazone.
A process for making pioglitazone, which comprises:
- reacting a sulfonylchloride of the formula R—SO2Cl with a compound of formula (7)
- wherein R represents a C1-C4 alkyl group or an optionally substituted phenyl group and R1 represents a C1-C4 alkyl group, to form a compound of formula (8)
- wherein R and R1 are as defined above;
- reacting said compound of formula (8) with thiourea to form the compound of formula (3):
- and hydrolyzing said compound of formula (3) to form pioglitazone of formula (1):
2 more elements
Dependencies are inferred from the claim text.