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US 2007/0167624 A1Published application
Process for preparing 1-methoxymethyl 5,5-diphenybarbituric acid
AssigneeTaro Pharmaceutical Industries Ltd.
InventorsDaniella Gutman, Rosa Cyjon
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Abstract
The present invention provides a novel process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid. In particular, the present invention provides a process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid by reacting 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid with a Lewis acid to selectively remove one methoxymethyl group from 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid.
Claims9
A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid comprising the steps of:
- (a) reacting 1,3-bis(methoxymethyl)-5,5-diphenylbarbituric acid with about 0.6 equivalent to about 1 equivalent of aluminum chloride, at a temperature of about 70° C. to about 130° C., for about two to about three hours;
- and
- (b) isolating the 1-methoxymethyl-5,5-diphenylbarbituric acid.
Dependencies are inferred from the claim text.