Thiazoles as inhibitors of 11B-hydroxysteroid dehydrogenase

A pharmaceutical composition, comprising a therapeutically effective amount of a compound according to formula (I):

• wherein:
• p1 R1 is 5- to 8-membered cycloalkyl,
• phenyl, unsubstituted or mono-, bi-, or tri-substituted independently with halogen, lower alkyl, halo-lower-alkyl, phenyl, —OCH3, —O(CH2)nCH3, —(CH2)nOH, —OH, —NH2, —OCF3, —O(CH2)n-phenyl, —SCH3, —NHSO2CH3, thiophene, morpholine, —C(O)CH3, —N(CH3)2 or —NO2,
• 5- or 6-membered saturated, partially unsaturated, or aryl ring which is connected by a ring carbon atom and which has from 1 to 3 hetero ring atoms selected from the group consisting of sulfur, nitrogen and oxygen, unsubstituted or substituted with halogen, lower alkoxy, or lower alkyl,
• 9- or 10-membered bicyclic unsaturated or partially unsaturated ring which is connected by a ring carbon and which has from 1 to 3 hetero ring atoms selected from the group consisting of sulfur, nitrogen and oxygen, unsubstituted or mono-, bi- or tri-substituted with halogen or lower alkyl;
• one of R2 or R3 is H or branched or unbranched lower alkyl, and the other is C4-C10 alkyl, —CH2-phenyl, mono-, bi- or tri-cyclic 5- to 10-membered carbocyclic ring unsubstituted or mono- or bi-substituted with lower alkyl, hydroxy, or oxo, or bicyclic partially unsaturated 9- or 10-membered ring,
• or
• R2 and R3, together with the N atom to which they are attached, form a saturated or partially unsaturated 6- to 8-membered monocyclic or 7- to 10-membered bicyclic ring, which contains the N atom to which R2 and R3 are attached, and optionally another hetero atom which is selected from O and S, unsubstituted or mono- or bi-substituted with branched or unbranched lower alkyl, halogen, hydroxy, hydroxy-alkyl, pyridine, carboxy, phenyl, oxo, —CH2-phenyl or 5- to 10-membered cycloalkyl;
• and
• n is zero, 1 or 2,
• or a pharmaceutically acceptable salt thereof,
• and a pharmaceutically acceptable carrier.

A method for treating a metabolic disease or disorder, comprising the step of administering to a patient in need thereof a therapeutically effective amount of a compound according to formula (I):

• wherein:
• R1 is 5- to 8-membered cycloalkyl,
• phenyl, unsubstituted or mono-, bi-, or tri-substituted independently with halogen, lower alkyl, halo-lower-alkyl, phenyl, —OCH3, —O(CH2)nCH3, —(CH2)nOH, —OH, —NH2, —OCF3, —O(CH2)n-phenyl, —SCH3, —NHSO2CH3, thiophene, morpholine, —C(O)CH3, —N(CH3)2 or —NO2,
• 5- or 6-membered saturated, partially unsaturated, or aryl ring which is connected by a ring carbon atom and which has from 1 to 3 hetero ring atoms selected from the group consisting of sulfur, nitrogen and oxygen, unsubstituted or substituted with halogen, lower alkoxy, or lower alkyl,
• 9- or 10-membered bicyclic unsaturated or partially unsaturated ring which is connected by a ring carbon and which has from 1 to 3 hetero ring atoms selected from the group consisting of sulfur, nitrogen and oxygen, unsubstituted or mono-, bi- or tri-substituted with halogen or lower alkyl;
• one of R2 or R3 is H or branched or unbranched lower alkyl, and the other is C4-C10 alkyl, —CH2-phenyl, mono-, bi- or tri-cyclic 5- to 10-membered carbocyclic ring unsubstituted or mono- or bi-substituted with lower alkyl, hydroxy, or oxo, or bicyclic partially unsaturated 9- or 10-membered ring,
• or
• R2 and R3, together with the N atom to which they are attached, form a saturated or partially unsaturated 6- to 8-membered monocyclic or 7- to 10-membered bicyclic ring, which contains the N atom to which R2 and R3 are attached, and optionally another hetero atom which is selected from O and S, unsubstituted or mono- or bi-substituted with branched or unbranched lower alkyl, halogen, hydroxy, hydroxy-alkyl, pyridine, carboxy, phenyl, oxo, —CH2-phenyl or 5- to 10-membered cycloalkyl;
• and
• n is zero, 1 or 2,
• or a pharmaceutically acceptable salt thereof.