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US 2007/0167606 A1Published application
Polyethylene glycol aldehydes
OwnerChee-Youb Woninventor
Life of this patent
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Abstract
Polyethylene glycol aldehyde compounds are provided. Methods of making and using such compounds, as well as chemical intermediates are also provided.
Claims86
A compound of formula (l):
- R1—(CH2CH2O)n—CH2CH2—X—Y—NH—(CH2)p—CHO (I)
- wherein
- R1 is a capping group,
- X is O or NH,
- Y is selected from the group consisting of
- Z is a side chain of an amino acid,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
6 more elements
A compound of formula (Il):
- wherein
- R1 is a capping group,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
2 more elements
A compound of formula (VIII):
- wherein
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
1 more element
A compound of formula (IX):
- R1—(CH2—CH2—O)n—CH213 CH2—X—Y—NH—(CH2)p—CH(OCH2—CH3)2 (IX)
- wherein
- R1 is a capping group,
- X is O or NH,
- Y is selected from the group consisting of
- Z is a side chain of an amino acid,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
6 more elements
A compound of formula (X):
- wherein
- R1 is a capping group,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
2 more elements
A compound of formula (XI):
- wherein
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
1 more element
A method of making a polyethylene glycol aldehyde comprising hydrolyzing a compound of formula (IX):
- R1—(CH2—CH2—O)n—CH2CH2—X—Y—NH—(CH2)p—CH—(OCH2—CH3)2 (IX)
- to produce a polyethylene glycol aldehyde of formula (I):
- R1—(CH2CH2O)n—CH2CH2—X—Y—NH—(CH2)p—CHO (I)
- wherein
- R1 is a capping group,
- X is O or NH,
- Y is selected from the group consisting of
- Z is a side chain of an amino acid,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
8 more elements
A method of making a polyethylene glycol aldehyde comprising hydrolyzing a compound of formula (X):
- to produce a polyethylene glycol aldehyde of formula (II):
- wherein
- R1 is a capping group,
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
3 more elements
A method of making a polyethylene glycol aldehyde comprising hydrolyzing a compound of formula (XVII):
- to produce a polyethylene glycol of formula (Vil):
- wherein
- m is from 1 to 17,
- n is from 10 to 10,000, and
- p is from 1 to 3.
2 more elements
Dependencies are inferred from the claim text.