Unsaturated poly(ester-amide) biomaterials
AssigneeCornell Research Foundation, Inc.
InventorsChih-Chang Chu, Ramaz Katsarava, Kai Guo
Life of this patent
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Abstract
Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.
Claims18
A polymer having the structural formula:
- wherein R1 is selected from the group consisting of (C2-C20) alkylene and (C2-C20) alkenylene;
- R3 is selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl and (C6-C10) aryl(C1-C6) alkyl;
- and R4 is selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, and ((CH2)rO)q-(C2-C20) alkylene where r is 2 or 3 and q ranges from 1 to 4, where at least one of R1 and R4 comprises a radical selected from the group consisting of (C2-C20) alkenylene;
- and n ranges from about 5 to about 150.
A polymer having the structural formula:
- where m ranges from about 0.1 to about 0.9;
- p ranges from about 0.9 to about 0.1;
- n ranges from about 5 to about 150, each R1 is independently selected from the group consisting of (C2-C20 alkylene), and (C2-C20) alkenylene;
- R2 is hydrogen or (C6-C10)aryl (C1-C6) alkyl or t-butyl or other protecting group;
- R3 is selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl and (C6-C10) aryl (C1-C6) alkyl;
- and R4 is selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, and ((CH2)rO)q-(C2-C20) alkylene where r is 2 or 3 and q ranges from 1 to 4, where one R1 and R4 or both R1s and R4 or both R1s but not R4 or one R1 and not R4 or R4 but no R1s comprise a radical selected from the group consisting of (C2-C20) alkenylene.
Dependencies are inferred from the claim text.