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US 2007/0167525 A1Published application
Combinations of metformin and a meglitinide
OwnerBard Geesamaninventor
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Abstract
Methods of treating glucose related disorders, for example by administering a meglitinide such as mitiglinide, repaglinide, or nateglinide, optionally in combination with a biguanide such as metformin, are described herein.
Claims30
A method of treating or prophylactically treating diabetes in a subject, the method comprising:
- administering to a subject a meglitinide, at least twice a day, wherein at least one meal is consumed by the subject without the administration of a dose of a meglitinide, thereby treating said subject and
- further comprising administering a biguanide, at least one time per day.
A pharmaceutical composition comprising mitiglinide and biguanide.
A method of titrating a subject for a meglitinide, the method comprising:
- administering increasing doses of the meglitinide to the subject, and
- evaluating the subject for tolerance to the meglitinide as the dose is increased.
Dependencies are inferred from the claim text.